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Clinical Trials for Research Opportunities |
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Special Tissue Banking Study for Selected Tumors
Eligibility Requirements
• Golden retrievers with lymphoma, Scottish terriers with transitional cell carcinoma, dogs of any breed with oral melanoma. Bulky tumor amenable to surgery must be present.
Study Objective
This study is a multi-institutional effort to evaluate tissue and blood samples for special testing. The study involves taking a biopsy (or use of a piece of tissue from a therapeutic surgery to remove the tumor), blood collection, and cheek swab.
Compensation
The cost of biopsy or a portion of the surgery is covered by the study. The cost of cystoscopy is covered for dogs with transitional cell carcinoma. There is no cost for collection of blood or cheek swab samples. Owners will receive $1,000 toward further veterinary care at Tufts for the participation in this study.
Location of Trial
North Grafton, MA
More information
Canine comparative oncology and genetics consortium (CCOGC) tissue bank.
Eligibility Requirements
• Canine patients who have been diagnosed with lymphoma and who have not received any prior treatment are eligible. Patients must have a surgically accessible lymph node and be healthy enough to tolerate the anesthetic and surgical procedure associated with lymph node removal. In addition we would like to obtain 1.5 tablespoons (22 cc) of blood and a urine sample from your pet at the time samples are taken for other diagnostic tests.
Study Objective
The purpose of this study is to help populate a national tumor tissue bank or archive. The primary mission of the CCOGC is to improve the diagnosis and treatment of cancer and other diseases in dogs. There may also be benefits to human patients diagnosed with similar types of cancers. The collective information from several thousand tissue samples form dogs will contribute important knowledge about our understanding of cancer, its prevention, early diagnosis and treatment.
Compensation
Special financial considerations will be given to the clients for their pet's participation in this study. The study will cover the costs of lymph node excision and will provide a $300 credit toward your pets continued treatment. Please click on the link for more details.
Location of Trial
Davis, CA
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Canine Cancer Diagnostics Sampling Program
Eligibility Requirements
• Mast Cell Tumor
• Melanoma
• Naïve Lymphoma
• Relapsed Lymphoma
• Liver Cancer (primary)
• Lung Cancer (primary)
• Prostate Cancer
• Squamous Cell Carcinoma
• Adenocarcinoma (Ex: Salivary, Nasal, Tonsillar, Anal Sac)
• GI Cancer
• Transitional Cell Carcinoma (bladder)
• Breast or Ovarian Cancer
Study Objective
ACI is conducting a blood sample collection project in dogs with various forms of cancer. A small amount of whole blood (less than a teaspoon) will be collected from dogs that are eligible. Dogs of any age, breed, size, or stage are eligible. Eligible dogs may be newly diagnosed, currently receiving therapy, in remission or not, and/or have been previously treated.
Compensation
Please click on the link for more details.
Location of Trial
Please click on link below for location details.
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Canine Tumor Sample Collection Study
Eligibility Requirements
• Mast Cell Tumor
• Hemangiosarcoma
• Osteosarcoma
Study Objective
ACI is conducting a tumor sample collection project in dogs with various forms of cancers. Dogs that are at least 1 year in age, of any breed, size, sex, or stage are eligible. Eligible dogs may be newly diagnosed, naïve, or relapsed patients that have received and/or failed prior chemotherapy.
Compensation
Please click on the link for more details.
Location of Trial
Various Locations (click on link below for details)
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Study NA Pilot Study to Assess Feasibility of Tissue Collections and Molecular Profiling for future Comparative Oncology Personalized Medicine
Eligibility Requirements
One of the following:
• Scottish terriers with transitional cell carcinoma of the bladder
• Golden retrievers with multi-centric lymphoma
• American cocker spaniels with oral melanoma
• creatinine > 3.0
• bilirubin > 2.0 or elevated bile acids
• HCT < 25%, platelets < 50,000
• any >grade 2 hematologic/biochemical abnormality
Study Objective
A pilot study in pet dogs with cancer is needed to determine the feasibility of tissue collection, clinical utility, and large-scale target interrogation across a multi-institutional setting. Data from this feasibility study will inform the design of a personalized therapeutic intent trial in pet dogs. Future comparative oncology modeling of novel personalized medicine strategies will hopefully progress the field and translate into more efficient targeted therapy prescriptions for human cancer patients.
Compensation
Please contact NCI for further information.
Location of Trial
Colorado State University
Purdue University
Tufts University
University of California at Davis
University of Florida
University of Georgia
University of Guelph
University of Michigan
University of Pennsylvania
University of Tennessee
University of Wisconsin
More information
Lymph node biopsy to evaluate tumor-infiltrating lymphocytes in dogs with lymphoma.
Eligibility Requirements
• Certain criteria determine patient eligibility. Canine patients with suspected B cell lymphoma are eligible for inclusion in this study. Patients may NOT have received previous chemotherapy for the treatment of their disease. Previous steroid treatment is accepted with a 7-day washout period. Patients should be in relatively good health.
Study Objective
We are investigating whether T lymphocytes (a type of lymphocyte that is very important in helping the body fight off cancer) could be used to help generate a powerful vaccine for the treatment of B cell lymphoma. Our lab’s previous research in mice has shown that stimulating T lymphocytes with mimotope vaccines—lab-created mimics of tumor molecules - causes T cells to respond aggressively against tumors and inhibits tumor growth. To determine whether we can generate similarly successful vaccines for dogs we first need to determine the quantity and quality of the T lymphocytes present within the lymph node of dogs with B cell lymphoma.
This will be done by harvesting a small portion of the lymph node collected from your dog at the time of surgical lymph node removal (excisional biopsy). We will then analyze this sample for particular characteristics of T lymphocytes to determine if the T cells could potentially be used to design an effective anti-cancer vaccine. We will also collect a small blood sample for lymphocyte analysis. We would also like to investigate whether certain T cell characteristics in either the blood or the lymph node are associated with outcome in dogs with lymphoma.
Compensation
Clients participating in this study will be given special financial considerations. The costs of lymph node excision, general anesthesia, histopathology and immunophenotyping will be covered by the study. Alternatively, if your dog is also participating in the CCOGC tissue archiving study, you will instead receive a $550.00 credit that can be applied to the cost of future diagnostics and/or treatments at the VTH. Please click on the link for more details.
Location of Trial
Fort Collins, CO
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The role of genetics in cancer that occurs in purebred dogs
Eligibility Requirements
• Cats and dogs with various types of cancers. Please click on link for more details..
Study Objective
There is an association between purebred dogs and the types of cancers that they develop. We believe these associations are due to hereditary factors that have been passed from generation to generation by the selective breeding of purebred dogs. It is our goal to investigate these associations and uncover the link between dog breeds and the kinds of cancers they are at increased risk of developing. This knowledge will aid in understanding the biological processes of cancer and improve our ability to diagnose and treat cancer in dogs.
Compensation
These studies may be partially funded. Please click on link for more details.
Location of Trial
East Lansing, MI
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Stomach cancer study in dogs
Eligibility Requirements
• Dogs of the following breeds Chow, Akita, Belgian sheepdog and tervuren, Bouvier, Irish Setter, Keeshond, Norwegian Elkhound and the Scottish Terrier.
o Either showing signs of stomach cancer or have been
diagnosed with stomach cancer OR
o No signs of stomach cancer and at least 8 years old
Study Objective
To determine the cause of stomach cancer in breeds that have an increased risk.
Compensation
This study is not funded. Please click on link for more details.
Location of Trial
East Lansing, MI
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Transitional cell carcinoma study in dogs
Eligibility Requirements
• Dogs of the following breeds: Highland White Terrier, Scottish Terrier, Shetland Sheep Dog or Beagle that is over the age of 7
o Either affected (has bladder cancer) OR
o Unaffected (does not have bladder cancer)
Study Objective
To determine the cause of bladder cancer West Highland White Terriers, Scottish Terriers, Shetland Sheep dogs and Beagles.
Compensation
This study is not funded. Please click on link for more details.
Location of Trial
East Lansing, MI
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Canine patients with osteosarcoma, lymphoma, or oral malignant melanoma, mast cell tumors, soft tissue sarcomas/histiocytic sarcoma/malignant histiocytosis, primary pulmonary cancer, hemangiosarcomas
Eligibility Requirements
• Requirements vary for each type of cancer listed above. Please click on link for more details.
Study Objective
The goal of the CCOGC and UC Davis will be to populate the Pfizer-CCOGC Biospecimen Repository with diseased tissues and specific normal tissues from dogs with cancer over the next three years.
Compensation
This study is partially funded. Please click on link for more details.
Location of Trial
Davis, CA: More information
North Grafton, MA: More information
Madison, WI: More information
Development of a canine model of radiotherapy-induced oral mucositis
Eligibility Requirements
• Dogs who have been diagnosed with cancer of the head and neck and evaluated at MJR-VHUP
• Owner has elected to pursue radiation therapy to treat their dog’s cancer
Study Objective
The purpose of this clinical research project is to gather data about the development and progression of oral mucositis and how it affects dogs’ behavior and quality of life. The results will be analyzed in the hope to develop more treatment options and relief for this condition.
Compensation
This study is partially funded. Please click on link for more details.
Location of Trial
Philadelphia, PA
For more information
Please visit: More information
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